Publications - COGD - 2003
<em>S. mediterranea</em> embryos Current Opinion in Genetics & Development
13: 438-444, 2003
The freshwater planarian Schmidtea mediterranea: embryogenesis, stem cells and regeneration
Alejandro Sánchez Alvarado
University of Utah School of Medicine, Department of Neurobiology and Anatomy, Salt Lake City, Utah


Planarians have been used as a model to study development and regeneration for more than 200 years. Research on these animals has traditionally focused on surgical and pharmacological manipulations. Recently, the dissection of planarians has become more molecular in nature. The isolation of thousands of ESTs and the introduction of in situ hybridizations, immunocytology, and RNA-mediated gene interference (RNAi) has opened the door to gene discovery and to the study of gene function in planarians during development and regeneration. These advances promise to shed mechanistic insight into basic biological attributes such as regeneration and stem cell regulation.

Click here to see a movie of S. mediterranea laying an egg

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